Biomedical Engineering - Carnegie Mellon University


Publications - Todd Przybycien

[1989a] Przybycien TM, JE Bailey Structure-function relationships in the inorganic salt-induced precipitation of alpha-chymotrypsin. Biochim Biophys Acta 995: 231-245

[1989b] Przybycien TM, JE Bailey Solubility-activity relationship in the inorganic salt-induced precipitation of alpha-chymotrypsin. Enzyme Microbial Technol 11: 264-276

[1989c] Przybycien TM, JE Bailey Aggregation kinetics in salt-induced protein precipitation. Am Inst Chem Eng J 35: 1779-1790

[1991a] Przybycien TM, JE Bailey Secondary structure perturbations in salt-induced protein precipitates. Biochim Biophys Acta 1076: 103-111

[1994a] Patro SY, TM Przybycien Simulations of kinetically irreversible protein aggregate structure. Biophys J 66: 1274-1289

[1994b] Przybycien TM, JP Dunn, P Valax, G Georgiou Secondary structure characterization of beta-lactamase inclusion bodies. Protein Eng 7: 131-136

[1994c] Yeo SD, PG Debendetti, SY Patro, TM Przybycien Secondary structure characterization of microparticulate insulin powders. J Pharm Sci 83: 1651-1656

[1994d] Iyer H, TM Przybycien Protein precipitation: effects of mixing on protein solubility. Am Inst Chem Eng J 40: 349-360

[1995a] Iyer HV, TM Przybycien Metal affinity protein precipitation: Effects of mixing, protein concentration, and modifiers on protein fractionation. Biotechnol Bioeng 48: 324-332

[1995b] Lam P, PR Elliker, GE Wnek, TM Przybycien Towards an electrochemically modulated chromatographic stationary phase. J Chromatography A 707: 29-33

[1996a] Patro SY, TM Przybycien Self-interaction chromatography: A tool for the study of protein-protein interactions in bioprocessing environments. Biotechnol Bioeng 52: 193-203

[1996b] Patro SY, TM Przybycien Simulations of reversible protein aggregate and crystal structure. Biophys J 70: 2888-2902

[1996c] Tzannis ST, WJ Hrushesky, PA Wood, TM Przybycien Irreversible inactivation of interleukin 2 in a pump-based delivery environment. Proc Natl Acad Sci U S A 93: 5460-5465

[1996d] Winters MA, BL Knutson, PG Debenedetti, HG Sparks, TM Przybycien, CL Stevenson, SJ Prestrelski Precipitation of proteins in supercritical carbon dioxide. J Pharm Sci 85: 586-594

[1996e] Iyer HV, TM Przybycien A Model for metal affinity protein aggregation. J Colloid Interface Sci 177: 391-400

[1997a] Winters MA, PG Debenedetti, J Carey, HG Sparks, SU Sane, TM Przybycien Long-term and high-temperature storage of supercritically-processed microparticulate protein powders. Pharm Res 14: 1370-1378

[1997b] Tzannis ST, WJM Hrushesky, PA Wood, TM Przybycien Adsorption of formulated interleukin-2 on drug delivery device surfaces. J Colloid Interface Sci 189: 216-228

[1998a] Przybycien TM Protein-protein interactions as a means of purification. Curr Opin Biotechnol 9: 164-170

[1999a] Lam P, K Kumar, GE Wnek, TM Przybycien A prototype electrochemical chromatographic column for use with proteins. Anal Chem 71: 4272-4277

[1999b] Sane SU, SM Cramer, TM Przybycien A holistic approach to protein secondary structure characterization using amide I band Raman spectroscopy. Anal Biochem 269: 255-272

[1999c] Winters MA, DZ Frankel, PG Debenedetti, J Carey, M Devaney, TM Przybycien Protein purification with vapor-phase carbon dioxide. Biotechnol Bioeng 62: 247-258

[1999d] Lam P, K Kumar, G Wnek, TM Przybycien Electroless gold plating of stainless 316L beads. J Electrochem Soc 146: 2517-2521

[1999e] Bohme P, G Vedantham, TM Przybycien, G Belfort Self-Assembled monolayers on polymer surfaces: kinetics, functionalization and photopatterning. Langmuir 15: 5323-5328

[1999f] Sane SU, SM Cramer, TM Przybycien Protein Structure Perturbations on Chromatographic Surfaces. J Chromatography A 849: 149-159

[2000a] Vedantham G, HG Sparks, SU Sane, S Tzannis, TM Przybycien A holistic approach for protein secondary structure estimation from infrared spectra in H(2)O solutions. Anal Biochem 285: 33-49

[2002a] Doherty EA, KD Berglund, BA Buchholz, IV Kourkine, TM Przybycien, RD Tilton, AE Barron Critical factors for high-performance physically adsorbed (dynamic) polymeric wall coatings for capillary electrophoresis of DNA. Electrophoresis 23: 2766-2776

[2002b] Srinivasan U, GH Iyer, TM Przybycien, WA Samsonoff, JA Bell Crystine: fibrous biomolecular material from protein crystals cross-linked in a specific geometry. Protein Eng 15: 895-902

[2003a] Ow Sullivan MM, JJ Green, TM Przybycien Development of a novel gene delivery scaffold utilizing colloidal gold-polyethylenimine conjugates for DNA condensation. Gene Ther 10: 1882-1890

[2003b] Choi EJ, MD Foster, S Daly, R Tilton, TM Przybycien, CF Majkrzak, P Witte, H Menzel Effect of flow on human serum albumin adsorption to self-assembled monolayers of varying packing density. Langmuir 19: 5464-5474

[2003c] Vedantham G, SL Carothers, G Belfort, TM Przybycien Structural response of bovine growth hormone to dead-ended ultrafiltration. Separation Sci Technol 38: 251-270

[2003d] Daly S, TM Przybycien, RD Tilton Coverage dependent orientation of lysozyme adsorbed on silica. Langmuir 19: 3848-3857

[2003e] Berglund KD, TM Przybycien, RD Tilton Coadsorption of sodium dodecylsulfate with hydrophobically modified nonionic cellulose polymers II: role of surface selectivity in adsorption hysteresis. Langmuir 19: 2714-2721

[2004a] Przybycien TM, NS Pujar, LM Steele Alternative bioseparation operations: life beyond packed-bed chromatography. Curr Opin Biotechnol 15: 469-478

[2004b] Sethuraman A, G Vedantham, T Imoto, T Przybycien, G Belfort Protein unfolding at interfaces: Slow dynamics of alpha-helix to beta-sheet transition. Protein Struct Func Bioinformatics 56: 669-678

[2004c] Berglund KD, MT Truong, RD Tilton, TM Przybycien, SG Garoff, LM Walker Rheology of transient networks containing hydrophobically modified cellulose, anionic surfactant and colloidal Silica: Role of Selective Adsorption. Rheol Acta 43: 50-61

[2005a] Daly SM, TM Przybycien, RD Tilton Adsorption of poly(ethylene glycol)-modified ribonuclease A to a poly(lactide-co-glycolide) surface. Biotechnol Bioeng 90: 856-868

[2005b] Daly SM, TM Przybycien, RD Tilton Adsorption of poly(ethylene glycol)-modified lysozyme to silica. Langmuir 21: 1328-1337

[2006a] Bartkovsky MJ, A Liao, GK Fedder, TM Przybycien, S Hauan The effect of a distributed mass loading on the frequency response of a MEMS mesh resonator. Conf Proc IEEE Eng Med Biol Soc 1: 1862-1865

[2007a] Daly SM, TM Przybycien, RD Tilton Aggregation of lysozyme and of poly(ethylene glycol)-modified lysozyme after adsorption to silica. Colloids Surf B Biointerfaces 57: 81-88

[2007b] Xiao Y, TT Jones, AH Laurent, JP O'Connell, TM Przybycien, EJ Fernandez Protein instability during HIC: hydrogen exchange labeling analysis and a framework for describing mobile and stationary phase effects. Biotechnol Bioeng 96: 80-93

[2007c] Valentine J, TM Przybycien, S Hauan Design of acoustic wave biochemical sensors using MEMS. J Appl Phys 101: 064508-1 - 064508-9

[2008a] Gaspard S, TM Przybycien, M Siegel Skin-color-compensated colorimeter for detection and classification of pressure Ulcers. IEEE Int Instru Measur Technol Conf 1542-1547

[2009a] Cisneros-Ruiz M, K Mayolo-Deloisa,TM Przybycien, M Rito-Palomares Separation of PEGylated from unmodified ribonuclease A using sepharose media. Sep Purif Technol 65: 105-109

[2010a] Ahmad MM, S Hauan, TM Przybycien Flowsheet simulation of aqueous two-phase extraction systems for protein purification. J Chem Technol Biotechnol 85: 1547-1670

[2010b] Pai SS, TM Przybycien, RD Tilton Protein PEGylation attenuates adsorption and aggregation on a negatively charged and moderately hydrophobic polymer surface Langmuir 26: 18231-18238

[2011a] Hum W, TM Przybycien Effect of curvature on the adsorption behavior of human serum albumin to polystyrene. Abstracts of Papers - American Chemical Society 241

[2011b] Kim AL, AC Wilcox, A DiIenno, TM Przybycien Connecting the aggregation behavior of human growth hormone to its colloidal and conformational stability. Abstracts of Papers - American Chemical Society 241

[2011c] Pai SS, B Hammouda, K Hong, DC Pozzo, TM Przybycien, RD Tilton The conformation of the poly(ethylene glycol) chain in mono-PEGylated lysozyme and mono-PEGylated human growth hormone. Bioconjugate Chemistry 22: 2317-2323

[2011d] Koch K, B Dew, TE Corcoran, TM Przybycien, RD Tilton, S Garoff Surface tension gradient driven spreading on aqueous mucin solutions: a possible route to enhanced pulmonary drug delivery. Molecular Pharmaceutics 8: 387-394

[2012a] Pai SS, F Heinrich, A Canady, TM Przybycien, RD Tilton Coverage-dependent morphology of PEGylated lysozyme layers adsorbed on silica. Journal of Colloid and Interface Science 370: 170-175

[2012b] Sharma R, R Kalita, E Swanson, TE Corcoran, S Garoff, TM Przybycien, RD Tilton Autophobing on liquid subphases driven by interfacial transport of amphiphilic molecules. Langmuir 28: 15212-15221

[2013a] Ahmad MM, TM Przybycien Towards Optimal Aqueous Two-Phase Extraction System Flowsheets for Protein Purification. Journal of Chemical Technology and Biotechnology 88: 62-71