Biomedical Engineering - Carnegie Mellon University


Publications - Phil LeDuc

[1999a] LeDuc P, C Haber, G Bao, D Wirtz Dynamics of individual flexible polymers in a shear flow. Nature 399: 564-566

[2000a] Ferri KF, E Jacotot, P Leduc, M Geuskens, DE Ingber, G Kroemer1 Apoptosis of syncytia induced by the HIV-1 envelope glycoprotein complex: influence of cell Shape and size. Exp Cell Res 261: 119-126

[2001a] Takayama S, E Ostuni, P LeDuc, K Naruse, DE Ingber, GM Whitesides Subcellular positioning of small molecules. Nature 411: 1016

[2002a] Castedo M, T Roumier, J Blanco, KF Ferri, J Barretina, LA Tintignac, K Andreau, JL Perfettini, A Amendola, R Nardacci, P Leduc, DE Ingber, S Druillennec, B Roques, SA Leibovitch, M Vilella-Bach, J Chen, JA Este, N Modjtahedi, M Piacentini, G Kroemer Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope. EMBO J 21: 4070-4080

[2002b] LeDuc P, E Ostuni, G Whitesides, D Ingber Use of micropatterned adhesive surfaces for control of cell behavior. Methods Cell Biol 69: 385-401

[2002c] Jiang X, S Takayama, X Qian, E Ostun, H Wu, N Bowden, P LeDuc, DE Ingber, GM Whitesides Controlling mammalian cell spreading and cytoskeletal arrangement with conveniently fabricated continuous Wavy features on poly(dimethylsiloxane). Langmuir 18: 3273-3280

[2003a] Brock A, E Chang, CC Ho, P LeDuc, X Jiang, GM Whitesides, DE Ingber Geometric determinants of directional cell motility revealed using microcontact printing. Langmuir 19: 1611-1617

[2003b] Takayama S, E Ostuni, P LeDuc, K Naruse, DE Ingber, GM Whitesides Selective chemical treatment of cellular microdomains using multiple laminar streams. Chem Biol 10: 123-130

[2003c] Takayama S, E Ostuni, X Qian, JC McDonald, X Jiang, P LeDuc, MH Wu, DE Ingber, GW Whitesides Topographical micropatterning of poly(dimethylsiloxane) using laminar flows of liquids in capillaries. Adv Mater 13: 570-574

[2004a] Kubicek JD, S Brelsford, P Ahluwalia, PR Leduc Integrated lithographic membranes and surface adhesion chemistry for three-dimensional cellular stimulation. Langmuir 20: 11552-11556

[2004b] Puskar K, L Apeltsin, S Ta'asan, R Schwartz, PR LeDuc Understanding actin organization in cell structure through lattice based Monte Carlo simulations. Mech Chem Biosyst 1: 123-131

[2005a] Shen N, D Datta, CB Schaffer, P LeDuc, DE Ingber, E Mazur Ablation of cytoskeletal filaments and mitochondria in live cells using a femtosecond laser nanoscissor. Mech Chem Biosyst 2: 17-25

[2005b] Cheng CM, B Li, PR Leduc Optical fabrication of three-dimensional polymeric microstructures. Appl Phys Lett 87: 164104

[2006a] Cheng CM, PR LeDuc Force-controlled inorganic crystallization lithography. J Am Chem Soc 128: 12080-12081

[2006b] Cheng CM, PR LeDuc Micropatterning polyvinyl alcohol as a biomimetic material through soft lithography with cell culture. Mol Biosyst 2: 299-303

[2006c] LeDuc PP, RR Bellin Nanoscale intracellular organization and functional architecture mediating cellular behavior. Ann Biomed Eng 34: 102-113

[2006d] Puskar K, S Ta 'asan, R Schwartz, PR LeDuc Evaluating spatial constraints in cellular assembly processes using a monte carlo approach. Cell Biochem Biophys 45: 195-201

[2006e] Yang JM, PR LeDuc Three-dimensional molecular phase separation and flow patterns with novel multilevel fluidics. Mol Cell Biomech 3: 69-77

[2006f] Wang Y, PR LeDuc Protein adsorption at the biomaterial/tissue interface. in An Introduction to Biomaterials pp.47-61

[2006g] Cheng CM, PR LeDuc Microdrilling for fabricating micrometer-scale holes in soft matter. Appl Phys A 85: 195-198

[2006h] Cheng CM, JD Kubicek, PR LeDuca Polymeric microlenses for real-time aqueous and nonaqueous organic imaging. Appl Phys Lett 88: 053902

[2007a] Cheng CM, PR LeDuc Creating ordered small-scale biologically-based rods through force-controlled stamping. J Am Chem Soc 129: 9546-9547

[2007b] Kuczenski B, PR LeDuc, WC Messner Pressure-driven spatiotemporal control of the laminar flow interface in a microfluidic network. Lab Chip 7: 647-649

[2007c] LeDuc P, R Schwartz Computational models of molecular self-organization in cellular environments. Cell Biochem Biophys 48: 16-31

[2007d] Leduc PR, MS Wong, PM Ferreira, RE Groff, K Haslinger, MP Koonce, WY Lee, JC Love, JA McCammon, NA Monteiro-Riviere, VM Rotello, GW Rubloff, R Westervelt, M Yoda Towards an in vivo biologically inspired nanofactory. Nat Nanotechnol 2: 3-7

[2007e] Puskar KM, A Parisi-Amon, S Ta'asan, R Schwartz, PR LeDuc Modeling molecular interactions to understand spatial crowding effects on heterodimer formations. Phys Rev E Stat Nonlin Soft Matter Phys 76: 041904

[2007f] Zhang Y, CM Cheng, B Cusick, PR LeDuc Chemically encapsulated structural elements for probing the mechanical responses of biologically inspired systems. Langmuir 23: 8129-8134

[2007g] Tafazzoli A, CM Cheng, C Pawashe, EK Sabo, L Trofin, M Sitti, PR Leduc Subfeature patterning of organic and inorganic materials using robotic assembly. J Mater Res 22: 1601-1608

[2007h] S Kumar, PR Leduc Dissecting the molecular basis of the mechanics of living cells. Exp Mech 49: 11-23

[2007i] Leduc PR, DN Robinson Using lessons from cellular and molecular structures for future materials. Adv Mater 19: 3761-3770

[2007j] Trofin L, PR LeDuc Controlled geometry fabrication of polydimethylsiloxane nanofibers for biomimetics. J Appl Polymer Sci 105: 2549-2552

[2008a] Helmick L, A Antunez de Mayolo, Y Zhang, CM Cheng, SC Watkins, C Wu, PR LeDuc Spatiotemporal response of living cell structures in Dictyostelium discoideum with semiconductor quantum dots. Nano Lett 8: 1303-1308

[2008b] Lee B, PR Leduc, R Schwartz Stochastic off-lattice modeling of molecular self-assembly in crowded environments by Green's function reaction dynamics. Phys Rev E Stat Nonlin Soft Matter Phys 78: 031911

[2008c] Lu YL, CM Cheng, PR LeDuc, MS Ho Controlling the mechanics and nanotopography of biocompatible scaffolds through dielectrophoresis with carbon nanotubes. Electrophoresis 29: 3123-3127

[2008d] Zhang Y, WC Ruder, PR LeDuc Artificial cells: building bioinspired systems using small-scale biology. Trends Biotechnol 26: 14-20

[2008e] Huang X, CM Cheng, L Wang, B Wang, CC Su, MS Ho, PR LeDuc, Q Lin Thermally tunable polymer microlenses. Appl Physs Lett 92: 251904

[2008f] Cheng CM, PR LeDuc Structural phase coexistence under reversible thermal control. Adv Mater 20: 953-958

[2008g] Cheng CM, PR Leduc Creating cellular and molecular patterns via gravitational force with liquid droplets. Appl Phys Lett 93: 174106

[2009a] Cheng CM, RL Steward, Jr., PR LeDuc Probing cell structure by controlling the mechanical environment with cell-substrate interactions. J Biomech 42: 187-192

[2009b] Chou SY, CM Cheng, PR Leduc Composite polymer systems with control of local substrate elasticity and their effect on cytoskeletal and morphological characteristics of adherent cells. Biomaterials 30: 3136-3142

[2009c] Kuczenski B, WC Ruder, WC Messner, PR Leduc Probing cellular dynamics with a chemical signal generator. PLoS ONE 4: e4847

[2009d] Lin YW, CM Cheng, PR Leduc, CC Chen Understanding sensory nerve mechanotransduction through localized elastomeric matrix control. PLoS ONE 4: e4293

[2009e] Kumar S, PR Leduc Dissecting the Molecular Basis of the Mechanics of Living Cells. Exp Mech 49: 11-23

[2009f] Leuba SH, TB Wheeler, CM Cheng, PR LeDuc, M Fernandez-Sierra, E Quinones Structure and dynamics of single DNA molecules manipulated by magnetic tweezers and or flow. Methods 47: 214-222

[2009g] Bellin RM, JD Kubicek, MJ Frigault, AJ Kamien, RL Steward Jr, HM Barnes, MB DiGiacomo, LJ Duncan, CK Edgerly, EM Morse, CY Park, JJ Fredberg, CM Cheng, and PR LeDuc Defining the role of syndecan-4 in mechanotransduction using surface-modification approaches Prod Natl Acad Sci USA 52: 22102-22107

[2009h] Yang JM, JE Didier, TR Cassino, PR LeDuc Spatiotemporal control of apical and basal living subcellular chemical environments through vertical phase separation. Small 5: 1984-1989

[2009i] Kim YT, B Kuczenski, PR LeDuc, WC Messner Modulation of fluid resistance and capacitance for long-term, high-speed feedback control of a microfluidic interface. Lab Chip 9: 2603-2609

[2009j] Cheng CM, YT Kim, JM Yang, SH Leuba, PR LeDuc Dynamics of individual polymers using microfluidic based microcurvilinear flow. Lab Chip 9: 2339-2347

[2009k] Cheng CM, K Matsuura, IJ Wang, Y Kuroda, PR LeDuc, K Naruse Fabricating small-scale, curved, polymeric structures with convex and concave menisci through interfacial free energy equilibrium. Lab Chip 9: 3306-3309

[2011a] Kim YT, SD Joshi, WC Messner, PR LeDuc, LA Davidson Detection of dynamic spatiotemporal response to periodic chemical stimulation in a Xenopus embryonic tissue. PLoS ONE 6, e14624

[2011b] Wilson ME, N Kota, YT Kim, Y Wang, DB Stolz, PR LeDuc, OB Ozdonganlar Fabrication of circular microfludic channels by combining mechanical micromilling and soft lithography. Lab Chip 11: 1550-1555

[2011c] LeDuc PR, WC Messner, JP Wikswo How Do Control-Based Approaches Enter into Biology? Annual Reviews of Biomedical Engineering 13: 369-396

[2011d] Li Z, Y Zhang, PR LeDuc, KB Gregory Microbial Electricity Generation via Microfluidic Flow Control. Biotechnology and Bioengineering 108: 2061-2069

[2011e] Zeng Y, T Lai, C Koh, PR LeDuc, KH Chiam Investigating Circular Dorsal Ruffles through Varying Substrate Stiffness and Mathematical Modeling. Biophysical Journal, 101: 2122-2130

[2011f] Kim Y, SD Joshi, LA Davidson, PR LeDuc, WC Messner Dynamic Control of 3D Chemical Profiles with a Single 2D Microfluidic Platform. Lab on a Chip 11: 2182-2188

[2011g] Cheng CM, JT Dawson, Q Guo, PR LeDuc, B Li Maskless fabrication of small-scale structures through controlling phase interactions. Applied Physics A 102: 185-188

[2011h] Kang J, RL Steward, YT Kim, R Schwartz, PR LeDuc, KM Puskar Response of an Actin Filament Network Model under Cyclic Stretching through a Coarse Grained Monte Carlo Approach. Journal of Theoretical Biology 274: 109-119

[2011i] Cheng CM, PR LeDuc, YW Lin Localized Bimodal Response of Neurite Extensions and Structural Proteins in Dorsal-Root Ganglion Neurons with Controlled Polydimethylsiloxane Substrate Stiffness. Journal of Biomechanics 44: 856-862

[2011j] Lee B, PR LeDuc, R Schwartz Unified Regression Model of Binding Equilibria in Crowded Environments. Scientific Reports (Nature Publishing Group) 1: 97

[2011k] Hazar M, RL Steward, CJ Chang, CJ Orndoff, Y Zeng, MS Ho, PR LeDuc, CM Cheng Modulating Material Interfaces Through Biologically-inspired Intermediates. Applied Physics Letters 99: 233701

[2011l] Steward RL, CM Cheng, JD Ye, RM Bellin, PR LeDuc Mechanical stretch and shear flow induced reorganization and recruitment of fibronectin in fibroblasts. Scientific Reports (Nature Publishing Group) 1: 1-12

[2011m] Chou S, CM Cheng, YW Lin, CC Chen, PR LeDuc Localized Neurite Outgrowth Sensing through Micropatterned Elastic Substrates. Soft Matter 21: 9871-9877

[2011n] Ruder WC, PR LeDuc Bioinspirations: Cell-Inspired Small-Scale Systems for Enabling Studies in Experimental Biomechanics. Integrative and Comparative Biology (Former journal name: American Zoologist) 51: 128-132

[2012a] Ruder WC, PR LeDuc Cells Gain Traction in 3D. Proceedings of the National Academy of Sciences 109: 11060-11061

[2012b] Tan C, J Lo, PR LeDuc, CM Cheng Frontiers of Optofluidics in Synthetic Biology. Lab Chip 12: 3654-3665

[2012c] Kim YT, WC Messner, PR LeDuc Disruptive Microfluidics: From Life Sciences to World Health to Energy. Disruptive Science and Technology 1: 41-53

[2012d] Ruder WC, ED Pratt, NZD Brandy, D LaVan, PR LeDuc, JA Antaki Calcium Signaling is Gated by a Mechanical Threshold in Three-Dimensional Environments. Scientific Reports 2: 554

[2012e] Didier JE, CM Schafer, PR LeDuc Programmed Biologically Inspired Synthetic Templating of Multifunctional Nanoarchitectures for Small-Scale Reactions. European Journal of Inorganic Chemistry 32: 5405-5410

[2012f] Lee B, PR LeDuc, R Schwartz Three-Dimensional Stochastic Off-Lattice Model of Binding Chemistry in Crowded Environments. PLoS One 7, e30131

[2012g] Cassino TR, L Drowley, M Okada, SA Beckman, B Keller, K Tobita, PR LeDuc, J Huard Mechanical Loading of Stem Cells for Improvement of Transplantation Outcome in a Model of Acute Myocardial Infarction: The Role of Loading History. Tissue Engineering Part A 18: 1101-1108

[2012h] Ruder WC, ED Pratt, S Bakhru, M Sitti, S Zappe, CM Cheng, JA Antaki, PR LeDuc Three-Dimensional Microfiber Devices that Mimic Physiological Environments to Probe Cell Mechanics and Signaling. Lab Chip 12: 1775-1779

[2012i] Ruder WC, DH Chia-Pei, BD Edelman, R Schwartz, PR LeDuc Biological Colloid Engineering: Self-Assembly of Dipolar Ferromagnetic Chains in a Functionalized Biogenic Ferrofluid. Appl. Phys. Lett. 101: 063701